Study of Steric Hindrance of Ketone Ester Reduction Chemistry

Drug Discovery Research (DDR) is a process by which new potential therapeutic entities are recognized. Lead discovery and Computer aided drug two most popular methods in DDR. However, chemical modification such as development of the linker gains its popularity various classes. In this poster, we proposing four steps starting from commercially available amino acids their routes for synthesizing linkers. We hypothesize that more sterically hindered R group on Amino Acid will result an increase diastereomer ratio (DR) reduction chemistry. poster discuss detailed reaction methods, data, how it’s being proposed anti-cancer agent.